Amanda (Amy) Boyle

Dr. Boyle worked in the Pharmacy Department at the University of Toronto for 5 years in PET radiopharmaceutical development and preclinical oncology imaging prior to obtaining her PhD from the University of Toronto in Radiopharmaceutical Sciences. With over 10 years of PET imaging experience Dr. Boyle joined the Brain Health Imaging Centre at CAMH for her post-doctoral training and then as an Independent Scientist, applying her knowledge of PET imaging oncology to neuroinflammation and neurodegenerative diseases.

Appointments

Independent Scientist. Brain Health Imaging Centre, CAMH

Research Interests

Dr. Boyle is an independent scientist at CAMH specializing in PET imaging and radiopharmaceuticals. Her research focuses on identifying biomarkers that are common to oncology and neuroinflammatory/neurodegenerative diseases through PET imaging. In recent work she studied the neuroinflammatory and neurodegenerative biomarkers cyclooxygenases-1 and -1, and glycogen synthase kinase-3 in preclinical models of oncology. She has also studied PET imaging oncology biomarkers in neuroinflammation and multiple sclerosis models. The overall goal of Dr. Boyle’s work is to hasten the development of effective PET imaging agents for oncology by learning from neuroinflammation, and vice versa.

Recent Publications

1. Boyle AJ, Narvaez A, Tong J, Zoghbi S, Pike VW, Innis RB, Vasdev N. Repurposing [¹¹C]MC1 for PET imaging of cyclooxygenase-2 in colorectal cancer xenograft mouse models. Mol Imaging Biol. 2021. DOI 10.1007/s11307-021-01675-0.
2. Boyle AJ, Tong J, Zoghbi S, Pike VW, Innis RB, Vasdev N. Repurposing [¹¹C]PS13 for PET imaging of cyclooxygenase-1 (COX-1) in ovarian cancer xenograft mouse models. J Nucl Med. 2021. ePub ahead of print. DOI: 10.2967/jnumed.120.249367.
3. Lindberg A^†, Boyle AJ^†, Tong J, Harkness MB, Garcia A, Tran T, Zhai D, Liu F, Donnelly DJ, Vasdev N. Radiosynthesis of [¹¹C]ibrutinib via Pd-mediated [¹¹C]CO carbonylation: Preliminary PET imaging in EAE mice. Front Nucl Med. 2021. DOI 10.3389/fnume.2021.772289.
4. Boyle AJ, Gaudet VC, Black SE, Vasdev N, Rosa-Neta P, Zukotynski KA. Artificial intelligence for molecular neuroimaging. Ann Transl Med. 2021:9(9). DOI:10.21037/atm-20-6220.
5. Duffy IR^†, Boyle AJ^†, Vasdev N. Improving PET imaging acquisition and analysis with machine learning: a narrative review with focus on Alzheimer’s disease and oncology. Mol Imaging. 2019 Jan-Dec; 18: 1536012119869070.