Caleb Browne

Dr. Caleb Browne is a scientist in the Brain Health Imaging Centre at the Centre for Addiction and Mental Health (CAMH).

Dr. Browne obtained his Master’s and PhD from the University of Toronto in the Department of Psychology, conducting his research at CAMH. After completing his graduate studies, Dr. Browne pursued further training at the Icahn school of medicine at Mount Sinai in New York where he completed an NSERC-sponsored Postdoctoral Fellowship and subsequently held a junior faculty position as an instructor. He then returned to returned to CAMH and the University of Toronto as faculty.

Areas of Research

Dr. Browne's research focuses on delineating brain mechanisms coordinating motivation and how dysfunctions in these processes contribute to addiction. A primary goal of his work is to identify and reverse persistent, drug-induced neurobiological changes that contribute to relapse – a major obstacle in effective addiction treatment. 

Specific Areas of Research:

• Epigenetic remodeling in substance use disorder
• Neural circuit mechanisms of motivation and addiction
• Serotonergic regulation of motivated behavior

The Browne lab employs sophisticated behavioral analysis in rodents, particularly through intravenous drug self-administration paradigms that enable modeling of voluntary drug intake. Integrating these methodologies with state-of-the-art techniques to profile and manipulate brain function across molecular and circuit levels, ongoing work spans multiple frontiers in neuroscience. The overarching goal of work in the Browne lab is to translate comprehensive preclinical insights into actionable treatment targets for addiction. At CAMH, this is facilitated by unparalleled collaborative opportunities across neuroscientific disciplines and synergies with clinically oriented research initiatives.

Publications
View Dr. Browne’s publications on Google Scholar.